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A new study has pinpointed a molecule that suppresses hunger after intense exercise. What is this all about it?
Paraphrasing Professor Andrew Huberman at Standford University who’s talking about how our hormones control our hunger. He said that anticipatory signals within our nervous system start thinking about the things that you happen to like to eat at that particular time of the day.


How is this happen? What is ghrelin?


The signal from ghrelin, which is a hormone that determines when we are hungry and when we have to eat is real and reduces glucose levels in the blood. And we want the glucose to be in a more modest range. But if it drops too low ghrelin is secreted from your gut and it activates neurons in your brain at various locations.
The ghrelin hormone and other neurons of the arcuate also activate the vmh in particular ways and it might even activate some of these neurons that are in the periphery of your mouth which actually makes you kind of salivate and want to eat.
I believe we all know about the pavlovian experiments on Pavlov’s dogs. They start celebrating the bell after the deal was presented with food. It turns out that these hormones are supported by the gut and can stimulate the neurons to create a sensation in the desire for certain foods at certain times of the day.
If you are somebody who eats breakfast at more or less the same time each day
 Let’s say 8:00 AM plus or minus 20 minutes and then we’d have lunch at 1230 plus or minus 20 minutes. But let’s say you’re somebody like me who typically skips breakfast and just eats lunch usually around 11:30 or 12 or something like that, you’re growing solution. And will start to match when you typically eat and it does that and is able to override the low levels of glucose in your bloodstream because the ghrelin system also gets input from a clock in your liver that is linked to the clock in your hypothalamus in your brain
What this means is if you eat at regular meal times you will start to get hungry a few minutes before there are most times. If you’ve ever wondered why your stomach kind of starts to growl because it’s a particular time of day. What you expect is not just the googling of liquids in your stomach, that’s not what it is. It’s actually a muscular phenomenon so well in a secluded as a kind of food anticipatory signal to get you motivated to go eat at regular times.
Nowadays there’s a lot of interesting intermittent fasting there. Is also a lot of interest in just what meal plans and schedules and what to eat in general in order to maximise one’s health and whole being and people have all sorts of cosmetic reasons and brains are using some metabolic reasons for wanting to control this kind of stuff.
Let’s make it really simple by first looking at the extremes some people need to eat every two or three hours then flip this I need to eat every two or three hours or else their blood sugar drops.
In general blood sugar doesn’t drop so low that they truly need to eat in order to alleviate a blood sugar issue.
Although sometimes that can happen so people are truly hypoglycaemics with low blood sugar most people as the blood sugar starts to head down towards the lowish ranges. For those people not eating on the cloud is very disruptive to them because it activates these hormones in the brain.
For people who eat once a day or twice a day what kind of shift their meals they might eat a lot but during a limited circle cheating window. It’s kind of interesting humans.
Whenever we push our muscles to exhaustion ‘lactate’ is what causes the burning sensation. Whereas phenylalanine is an amino acid that serves as a building block for proteins. Both combine to generate a chemical known as lac-phe, which is initiated by a protein known as CNDP2, which is particularly active in immune cells. Animals lacking this protein have been unable to generate lac-phe, causing them to eat more and gain weight than an experimental group with normal CNDP2 activity.
Lisa Kim went to find out the discovers from Stanford Medicine University

The researchers subsequently drew on a separate study being undertaken at Stanford University, in which evolutionary biologists assessed the growth of various chemicals in humans through and after periods of exercise. These findings not only indicated peaks in the same molecule, but the team also deconstructed its genetic structure, revealing it to be a mix of two natural sources of organic compounds: lactate and phenylalanine.

Whereas the results are crucial for our understanding of why exercise affects hunger hormones and can have minor and implicit weight loss advantages above merely burning fat, the scientists note that the research is still in its beginning stages.
Turning these findings into a form of health supplement that reduces appetite will be a long process that will start with a deeper knowledge of how lac-phe inhibits hunger signals and locating the neurotransmitters that allow this action.



Physical activity/daily exercise has been seen to enhance weight loss, manage appetite, and optimize the mitochondrial function, especially in patients who are overweight or obese,” stated Baylor College of Medicine co-corresponding author Dr Yong Xu.
Once we can understand the process by which exercise generates these improvements, we will be one step closer to assisting many people in managing their health.”
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